An Interventional Pain and Sports Medicine Practice

An Interventional Pain & Sports
Medicine Practice

Autoimmunity and Chronic Pain: New Therapies That Reduce Inflammation and Support Healing

Person clasping their hands tightly, representing chronic pain or inflammatory discomfort associated with autoimmune conditions.

Chronic pain is often treated as a purely structural problem involving joints, muscles, or nerves. However, in many patients, autoimmune and inflammatory processes are major underlying drivers of persistent pain. When the immune system becomes dysregulated, it can attack the body’s own tissues, leading to inflammation, tissue damage, nerve sensitization, and ongoing pain.

At the Barr Center for Innovative Pain & Regenerative Therapies in Virginia Beach, VA, we use an integrative, functional, and regenerative approach to identify immune-related contributors to pain and provide therapies such as low-dose naltrexone (LDN), peptide therapy, and GLP-1 metabolic therapy to help reduce inflammation and support healing.

How Autoimmunity Contributes to Chronic Pain

Autoimmune and inflammatory conditions can affect the joints, muscles, nerves, and connective tissues. Even when imaging appears normal, inflammation at the cellular level can drive pain.

Common autoimmune and inflammatory conditions associated with chronic pain include:

  • Rheumatoid arthritis
  • Psoriatic arthritis
  • Hashimoto’s thyroiditis
  • Lupus
  • Inflammatory bowel disease
  • Small fiber neuropathy
  • Fibromyalgia-like syndromes
  • Chronic tendon and ligament inflammation

Inflammation can also sensitize the nervous system, making pain signals stronger and more persistent.

The Link Between Immune Dysfunction and Nervous System Sensitization

Chronic inflammation activates immune cells called microglia, which live in the brain and spinal cord. When activated, these cells release inflammatory chemicals that amplify pain signaling.

This can contribute to:

  • Widespread pain
  • Nerve pain
  • Fatigue
  • Brain fog
  • Increased sensitivity to touch and movement

Reducing inflammation and calming immune activation is essential for long-term pain relief.

Dr. Barr has also described groundbreaking concepts in psychoneuroimmunology as a possible root contributor to chronic pain. You can create a link here to her book.

Low-Dose Naltrexone (LDN): A Powerful Tool for Immune Modulation

Low-dose naltrexone (LDN) is increasingly used to treat autoimmune and chronic inflammatory conditions. At low doses, naltrexone works very differently than its traditional use.

LDN helps by:

  • Reducing activation of inflammatory microglia
  • Supporting immune system balance
  • Increasing natural endorphin production
  • Reducing nerve inflammation
  • Improving pain sensitivity

LDN has been used to support patients with:

  • Fibromyalgia
  • Autoimmune diseases
  • Neuropathic pain
  • Chronic fatigue syndromes
  • Inflammatory pain conditions

Many patients experience improved pain, energy, and mental clarity.

Peptide Therapy to Reduce Inflammation and Promote Tissue Repair

Peptides are naturally occurring signaling molecules that help regulate healing and immune function.

BPC-157 and TB-500 Support Tissue Healing

These peptides help:

  • Reduce inflammation in joints and connective tissues
  • Accelerate healing of tendons and ligaments
  • Improve circulation to injured tissues
  • Support nerve healing

This can be especially helpful in autoimmune conditions where tissues are slow to heal.

KPV Peptide Helps Regulate Immune and Inflammatory Responses

KPV has powerful anti-inflammatory properties and may help:

  • Reduce systemic inflammation
  • Support gut health and intestinal barrier function
  • Improve immune system balance
  • Reduce inflammatory pain

Because gut health and immune function are closely linked, improving intestinal integrity can help reduce autoimmune activity.

GLP-1 Therapy: A New Approach to Reducing Inflammation and Chronic Pain

GLP-1 receptor agonists, commonly used for metabolic health and weight management, also have powerful anti-inflammatory effects. GLP-1 management is available through our partner, Hang 10.

GLP-1 therapy may help:

  • Reduce systemic inflammation
  • Improve immune regulation
  • Reduce nerve inflammation
  • Improve mitochondrial function and cellular energy
  • Reduce joint stress through weight reduction

Chronic inflammation is strongly linked to metabolic dysfunction. Improving metabolic health often improves pain.

Why a Functional and Regenerative Approach Is Essential

Chronic pain driven by autoimmune or inflammatory processes requires a comprehensive strategy.

At the Barr Center and our partner practice Hang 10, treatment may include:

  • Immune-modulating therapies such as LDN
  • Regenerative peptide therapy
  • GLP-1 metabolic and anti-inflammatory therapy
  • Hormone optimization
  • Nutritional and mitochondrial support
  • Regenerative injection therapies

This approach addresses both the root cause of inflammation and the damaged tissues themselves.

Conditions That May Benefit From Immune-Modulating Therapy

Patients with the following conditions may benefit:

  • Fibromyalgia
  • Chronic tendonitis
  • Neuropathic pain
  • Autoimmune disorders
  • Chronic joint pain
  • Persistent spine pain
  • Inflammatory conditions
  • Chronic fatigue with pain

Personalized Chronic Pain Treatment in Virginia Beach, VA

At the Barr Center for Innovative Pain & Regenerative Therapies and our partner Hang 10, we specialize in identifying the underlying causes of chronic pain and providing advanced therapies to reduce inflammation and support healing.

We serve patients throughout:

  • Virginia Beach
  • Norfolk
  • Chesapeake
  • Hampton Roads
  • Outer Banks and Northern North Carolina

Our goal is to help patients restore function, reduce pain, and improve quality of life.

Frequently Asked Questions About Autoimmunity and Chronic Pain

Can autoimmune disease cause chronic pain?

Yes. Autoimmune diseases cause inflammation that can damage joints, muscles, and nerves, leading to chronic pain.

What is low-dose naltrexone used for in chronic pain?

LDN helps regulate immune activity and reduce inflammation in the nervous system, which can improve pain and fatigue.

How do peptides help autoimmune-related pain?

Peptides such as BPC-157 and KPV help reduce inflammation and support tissue repair, which can improve healing and reduce pain.

Do GLP-1 medications reduce inflammation?

Yes. GLP-1 therapies reduce inflammatory signaling, improve metabolic health, and may help reduce chronic pain.

Who is a candidate for immune-modulating therapies?

Patients with chronic pain, autoimmune conditions, inflammation, or slow healing may benefit from these therapies.

INNOVATIVE PAIN & REGENERATIVE THERAPIES
INNOVATIVE PAIN & REGENERATIVE THERAPIES
Expert care for spine, joint, nerve, sports injuries, and chronic pain.

Find Relief From the Conditions Holding You Back

Dr. Lisa Barr is a leading pain management physician in Virginia Beach with over 35 years of experience diagnosing and treating spine, joint, nerve, and musculoskeletal pain. As a Board Certified PM&R specialist, she focuses on whole-body, non-surgical solutions that uncover the true root cause of pain. She is also the international bestselling author of Outsmart Your Pain and one of the region’s most experienced experts in regenerative medicine, PRP, and advanced biologic therapies.

Spinal Conditions
  • Neck Pain
  • Mid Back Pain
  • Low Back Pain
  • Pelvic Pain
  • SacroiIiac Joint Pain
  • Hypermobility
  • Myofascial Pain
    • Trigger Point
      injections
    • What is Sarapin?
  • Fibromyalgia
  • EOS/Hypermobility
    Syndrome
  • Autoimmunity
    • LDN (Low dose
      Natrexone)
    • Testing
  • Prolotherapy
  • Neuroprolotherapy
  • Neural Therapy
  • Cold Laser
  • Entrapment Neuropathy
    • Carpal Tunnel Syndrome
    • Radial & Ulnar Nerve Entrapment
    • Lower Extremity Entrapment
    • Occipital Neuritis
  • Scar Tissue
  • Peripheral Neuropathy
    • Fatty Acid Testing & Specialized Therapies
    • Cold Laser
    • Nutritional Support
  • Neck Pain
  • Mid Back Pain
  • Low Back Pain
  • Pelvic Pain
  • SacroiIiac Joint Pain
  • Hypermobility
  • Inner Arsenal
  • Vagus Nerve Support
  • Power over Pain Mindset
  • Breathing Practices
Resources

Chronic Pain Management Articles

Barr Center Video Playlist

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OVERVIEW

The Barr Center for Innovative Pain and Regenerative Therapies, led by Dr. Lisa Barr, is dedicated to helping people in pain. With over forty years of experience, Dr. Barr and her staff offer a range of evaluation and treatment options, including osteopathic assessment, trigger point injections, prolotherapy, and regenerative therapies. They prioritize a caring atmosphere and involve patients in their own care, ensuring they understand the recommended treatments. If necessary, they collaborate with other professionals to provide a comprehensive approach. Dr. Barr’s expertise has been recognized with the Top Doc award for thirty years.

FAQ

Pain Management and Treatment

The Barr Center for Innovative Pain & Regenerative Therapies is located at:

933 First Colonial Road, Suite 200
Virginia Beach, VA 23454

Phone: 757-578-2260
Email: info@BarrCenter.com

Monday–Thursday: 8:30 am–5:00 pm

Friday: Closed (note: physician on call)

Not always. Some insurance plans—especially HMOs—require a referral before seeing a specialist. To confirm what your specific plan requires, call your insurance provider or contact our office at 757-578-2260.

We accept most major insurance plans (except Medicaid). If your plan requires a referral or pre-authorization to see a specialist, you will need one for your first visit. After your initial consultation, our office obtains any future pre-authorizations, sometimes with assistance from your referring provider. Visit our Patient Resources page for details.

Yes. We offer telemedicine visits for certain appointment types, including follow-up visits and treatment discussions. Some procedures require in-office evaluation, and our team will help determine whether a virtual visit is appropriate.

Conditions and Treatment Questions

Led by pain management specialist Lisa Barr, M.D., the Barr Center provides comprehensive musculoskeletal and pain treatments including:

• Acupuncture
• Mind-body medicine and lifestyle optimization
• Interventional spinal procedures
• Sports medicine
• Physical therapy
• Regenerative medicine (PRP, prolotherapy)

We treat a wide range of pain and musculoskeletal conditions, including:

• Neck, shoulder, hip, back, and knee pain
• Sports injuries and repetitive strain conditions
• Posture, sleep, and movement-related pain
• Car accident injuries, including whiplash

Our approach provides proven alternatives to surgery and long-term medications through targeted injections, hands-on physical therapy, acupuncture, lifestyle guidance, and regenerative medicine.

If your pain is persistent, recurring, or limiting daily activities, it is time for an evaluation. We assess how your joints move, how your muscles function, and whether lifestyle factors are contributing to your symptoms.

We offer a comprehensive, root-cause approach to pain in a boutique practice setting.

Our team is highly specialized, and we combine interventional pain medicine, regenerative therapies, physical therapy, and whole-person care—all under one roof.

Our team includes board-certified physicians, licensed physical therapists, regenerative medicine specialists, acupuncture providers, and experienced clinical support staff with focused expertise in musculoskeletal medicine and pain management.

Preparing for your First Appointment

To help make your first visit efficient, please bring:

• Photo ID
• Insurance card
• Referral (if required by your insurance)
• Completed new-patient paperwork
• Co-pay, if applicable

If you have MRIs, CT scans, X-rays, or lab results, please have your referring provider fax them to our office. You may also download our Medical Records Request Form to expedite the process.

Experiencing Pain? Reach Out For Medication-Free Treatment