Barr Center for Innovative Pain & Regenerative Therapies
Barr Center for Innovative Pain
& Regenerative Therapies

Autoimmunity and Chronic Pain: How Immune Dysfunction May Be Driving Your Pain

Close-up of a person’s hands under teal lighting, gently holding and rubbing one finger with the other hand, suggesting discomfort or joint pain.

Many people living with chronic pain are told their MRI is “normal” or that their pain is simply due to wear and tear. But for many patients, the true driver of persistent pain may be something deeper: immune dysfunction and chronic inflammation.

At Barr Center for Innovative Pain & Regenerative Therapies in Virginia Beach, we frequently help patients uncover autoimmune and inflammatory contributors to chronic pain that have gone unrecognized for years.

By identifying and addressing immune dysregulation, we can often improve pain, reduce inflammation, and help patients heal more effectively.

What Is Autoimmunity?

Autoimmunity occurs when the immune system mistakenly attacks the body’s own tissues.

Rather than simply fighting infection, the immune system becomes overactive and creates ongoing inflammation that can damage:

  • Joints
  • Muscles
  • Tendons and ligaments
  • Nerves
  • Connective tissues
  • Internal organs

This chronic inflammatory response can create persistent pain even when structural imaging looks relatively normal.

How Autoimmune Disease Causes Chronic Pain

Autoimmune and inflammatory disorders can directly and indirectly drive pain through several mechanisms:

1. Tissue Inflammation and Damage

Immune attack on joints, connective tissue, or nerves creates inflammation and pain.

2. Nervous System Sensitization

Inflammation can make the nervous system hypersensitive, amplifying pain signals.

3. Poor Healing Capacity

Ongoing immune activation impairs tissue repair and recovery.

4. Central Pain Amplification

Immune activation in the brain and spinal cord can increase pain processing.

Autoimmune Conditions Commonly Associated With Chronic Pain

Many autoimmune and inflammatory disorders can contribute to persistent pain, including:

  • Rheumatoid arthritis
  • Psoriatic arthritis
  • Lupus
  • Hashimoto’s thyroiditis
  • Sjogren’s syndrome
  • Inflammatory bowel disease
  • Small fiber neuropathy
  • Fibromyalgia-like inflammatory syndromes
  • Undifferentiated connective tissue disease

The Role of Neuroinflammation in Chronic Pain

One of the most important emerging concepts in pain medicine is the role of neuroinflammation.

Immune cells in the central nervous system called microglia can become activated by chronic inflammation, infection, trauma, or autoimmune dysfunction.

When activated, microglia release inflammatory chemicals that amplify pain signaling and contribute to:

  • Widespread pain
  • Nerve pain
  • Brain fog
  • Fatigue
  • Sleep disruption
  • Increased pain sensitivity

This is one reason pain may persist even after an injury has structurally healed.

Advanced Therapies That May Help Reduce Autoimmune-Related Pain

At Barr Center, we use a comprehensive functional and regenerative medicine approach to address immune-mediated pain.

Low-Dose Naltrexone (LDN)

LDN may help:

  • Modulate immune function
  • Calm inflammatory microglia
  • Reduce neuroinflammation
  • Improve pain sensitivity
  • Increase endorphin production

LDN is commonly used in patients with fibromyalgia, autoimmune disease, neuropathic pain, and chronic fatigue.

Peptide Therapy

Certain peptides may support immune modulation and healing.

BPC-157 / TB-500

These may help:

  • Reduce inflammation
  • Support tendon and ligament healing
  • Improve tissue recovery
  • Promote nerve repair

KPV Peptide

May help:

  • Regulate inflammatory cytokines
  • Support gut barrier health
  • Reduce systemic immune activation
  • Improve autoimmune and inflammatory symptoms

 

Why a Functional Medicine Approach Matters

Traditional pain treatment often focuses only on symptoms.

At Barr Center, we look deeper to evaluate for root contributors such as:

  • Autoimmunity
  • Chronic inflammation
  • Gut dysfunction
  • Metabolic dysfunction
  • Hormonal imbalance
  • Nutrient deficiencies
  • Neuroinflammation
  • Impaired mitochondrial function

Treating the underlying drivers of inflammation can often significantly improve pain outcomes.

Who Should Consider an Autoimmune or Inflammatory Evaluation?

You may benefit from further immune and inflammatory workup if you have:

  • Chronic widespread pain
  • Pain without clear imaging findings
  • Fibromyalgia diagnosis
  • Unexplained fatigue with pain
  • Brain fog and inflammation
  • Slow healing after injury
  • Known autoimmune disease
  • Persistent tendon or ligament pain
  • Neuropathic symptoms

Chronic Pain and Autoimmune Treatment in Virginia Beach

At Barr Center for Innovative Pain & Regenerative Therapies, we specialize in identifying hidden inflammatory and autoimmune contributors to chronic pain.

We serve patients throughout:

  • Virginia Beach
  • Norfolk
  • Chesapeake
  • Suffolk
  • Hampton Roads
  • Outer Banks and Northern North Carolina

Our goal is to help patients reduce pain, restore function, and optimize healing through advanced functional, regenerative, and interventional therapies.

Schedule a Consultation

If chronic pain has not improved despite conventional treatment, immune dysfunction or inflammation may be playing a role.

Contact Barr Center for Innovative Pain & Regenerative Therapies today to schedule an evaluation and learn whether autoimmune or inflammatory factors may be contributing to your pain.

FAQ

Can autoimmune disease cause chronic pain?

Yes. Autoimmune disease can cause inflammation that damages joints, muscles, nerves, and connective tissue, leading to chronic pain.

What is neuroinflammation?

Neuroinflammation refers to inflammation in the brain and spinal cord that can amplify pain signaling and contribute to chronic pain syndromes.

Can low-dose naltrexone help autoimmune pain?

Low-dose naltrexone may help regulate immune activity and reduce neuroinflammation in some chronic pain and autoimmune conditions.

How do you test for autoimmune causes of pain?

Evaluation may include history, physical exam, inflammatory markers, autoimmune labs, metabolic assessment, and functional medicine testing when appropriate.

INNOVATIVE PAIN & REGENERATIVE THERAPIES
INNOVATIVE PAIN & REGENERATIVE THERAPIES
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Find Relief From the Conditions Holding You Back

Dr. Lisa Barr is a leading pain management physician in Virginia Beach with over 35 years of experience diagnosing and treating spine, joint, nerve, and musculoskeletal pain. As a Board Certified PM&R specialist, she focuses on whole-body, non-surgical solutions that uncover the true root cause of pain. She is also the international bestselling author of Outsmart Your Pain and one of the region’s most experienced experts in regenerative medicine, PRP, and advanced biologic therapies.

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OVERVIEW

The Barr Center for Innovative Pain and Regenerative Therapies, led by Dr. Lisa Barr, is dedicated to helping people in pain. With over forty years of experience, Dr. Barr and her staff offer a range of evaluation and treatment options, including osteopathic assessment, trigger point injections, prolotherapy, and regenerative therapies. They prioritize a caring atmosphere and involve patients in their own care, ensuring they understand the recommended treatments. If necessary, they collaborate with other professionals to provide a comprehensive approach. Dr. Barr’s expertise has been recognized with the Top Doc award for thirty years.

FAQ

Pain Management and Treatment

The Barr Center for Innovative Pain & Regenerative Therapies is located at:

933 First Colonial Road, Suite 200
Virginia Beach, VA 23454

Phone: 757-578-2260
Email: info@BarrCenter.com

Monday–Thursday: 8:30 am–5:00 pm

Friday: Closed (note: physician on call)

Not always. Some insurance plans—especially HMOs—require a referral before seeing a specialist. To confirm what your specific plan requires, call your insurance provider or contact our office at 757-578-2260.

We accept most major insurance plans (except Medicaid). If your plan requires a referral or pre-authorization to see a specialist, you will need one for your first visit. After your initial consultation, our office obtains any future pre-authorizations, sometimes with assistance from your referring provider. Visit our Patient Resources page for details.

Yes. We offer telemedicine visits for certain appointment types, including follow-up visits and treatment discussions. Some procedures require in-office evaluation, and our team will help determine whether a virtual visit is appropriate.

Conditions and Treatment Questions

Led by pain management specialist Lisa Barr, M.D., the Barr Center provides comprehensive musculoskeletal and pain treatments including:

• Acupuncture
• Mind-body medicine and lifestyle optimization
• Interventional spinal procedures
• Sports medicine
• Physical therapy
• Regenerative medicine (PRP, prolotherapy)

We treat a wide range of pain and musculoskeletal conditions, including:

• Neck, shoulder, hip, back, and knee pain
• Sports injuries and repetitive strain conditions
• Posture, sleep, and movement-related pain
• Car accident injuries, including whiplash

Our approach provides proven alternatives to surgery and long-term medications through targeted injections, hands-on physical therapy, acupuncture, lifestyle guidance, and regenerative medicine.

If your pain is persistent, recurring, or limiting daily activities, it is time for an evaluation. We assess how your joints move, how your muscles function, and whether lifestyle factors are contributing to your symptoms.

We offer a comprehensive, root-cause approach to pain in a boutique practice setting.

Our team is highly specialized, and we combine interventional pain medicine, regenerative therapies, physical therapy, and whole-person care—all under one roof.

Our team includes board-certified physicians, licensed physical therapists, regenerative medicine specialists, acupuncture providers, and experienced clinical support staff with focused expertise in musculoskeletal medicine and pain management.

Preparing for your First Appointment

To help make your first visit efficient, please bring:

• Photo ID
• Insurance card
• Referral (if required by your insurance)
• Completed new-patient paperwork
• Co-pay, if applicable

If you have MRIs, CT scans, X-rays, or lab results, please have your referring provider fax them to our office. You may also download our Medical Records Request Form to expedite the process.

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