An Interventional Pain and Sports Medicine Practice

An Interventional Pain & Sports
Medicine Practice

Low Dose Naltrexone (LDN) for Chronic Pain and Autoimmunity

LDN for chronic pain | Outsmart Your Pain | Barr Center | Virginia Beach, VA

Low dose naltrexone, also called LDN, is currently being studied in patients with several types of chronic pain, including migraines, fibromyalgia, and neuropathy. Other chronic pain conditions, certain cancers, and autoimmune-related disorders are also being explored. While research is still ongoing, low dose naltrexone is already being used widely in the United States for a variety of pain-related and autoimmune conditions.

Studies Show Low Dose Naltrexone Is Safe

Current research suggests that low dose naltrexone is a safe and cost-effective treatment option for chronic pain and autoimmunity. It is believed to work in the brain by reducing pro-inflammatory chemicals called cytokines, which can inflame and sensitize tissues throughout the body and contribute to pain.

By helping calm inflammation in the nervous system, low dose naltrexone may reduce pain and improve fatigue, sleep, mood, and overall physical function.

Low Dose Naltrexone vs. High Dose Naltrexone

Low dose naltrexone is very different from the standard 50 mg dose of naltrexone. High dose naltrexone has been FDA approved for many years for the treatment of drug and alcohol dependence. Low dose naltrexone, on the other hand, is considered investigational for chronic pain and autoimmune conditions.

LDN is generic and is often a cost-effective treatment option. Because it is only commercially available in the 50 mg dose, low dose naltrexone must be prepared by a compounding pharmacy.

While higher dose naltrexone has long been associated with addiction treatment, low dose naltrexone is used very differently and is not considered addictive. The quoted cost for compounded LDN is often around $50 per month, though pricing can vary by pharmacy.

Low Dose Naltrexone for Cancer and Other Conditions

Low dose naltrexone has also been studied in cancer-related research for its possible effects on immune function and gene expression. It has also shown potential benefit in certain brain and nervous system disorders, including multiple sclerosis, ALS, and Parkinson’s disease.

This prescription medication is not addictive. However, it should be used with caution in patients who are currently taking opioids, including tramadol. Low dose naltrexone works by blocking opioid receptors throughout the body for several hours. To avoid possible drug interactions, opioid pain medications may need to be discontinued or reduced before starting treatment. This should always be evaluated on an individual basis.

Low Dose Naltrexone Dosage and Treatment Guidance

The starting dose is typically 0.5 mg to 1.0 mg and is gradually increased up to a target dose of 4.0 to 4.5 mg, depending on the patient’s response and treatment plan. In many cases, patients begin with 1.0 mg and increase gradually over time until relief is reached or the maximum dose is achieved.

Some patients take low dose naltrexone at bedtime, while others may do better with a morning dose if sleep disruption occurs. Dosing should always be guided by the prescribing provider.

Naltrexone Side Effects

Side effects of low dose naltrexone are uncommon and are usually mild. Some people report vivid dreams during the first week or two of treatment. Less common side effects may include fatigue, anxiety, and dizziness.

Side effects are much more common at the higher doses used for addiction treatment and are rarely seen with typical low-dose use.

Who Should Use Caution with LDN

People with organ transplants and those taking immunosuppressive medications may need to avoid low dose naltrexone or use it only under close medical supervision. In addition, people with Hashimoto’s thyroiditis should use this medication with caution, as thyroid medication may need to be adjusted in the early stages of treatment.

Compounding Pharmacies

Pharmacy Innovations: (757) 934-0533
Lawrence Pharmacy in Chesapeake, VA: (757) 487-3458
Hague Pharmacy at CHKD: (757) 622-0222

INNOVATIVE PAIN & REGENERATIVE THERAPIES
INNOVATIVE PAIN & REGENERATIVE THERAPIES
Expert care for spine, joint, nerve, sports injuries, and chronic pain.

Find Relief From the Conditions Holding You Back

Dr. Lisa Barr is a leading pain management physician in Virginia Beach with over 35 years of experience diagnosing and treating spine, joint, nerve, and musculoskeletal pain. As a Board Certified PM&R specialist, she focuses on whole-body, non-surgical solutions that uncover the true root cause of pain. She is also the international bestselling author of Outsmart Your Pain and one of the region’s most experienced experts in regenerative medicine, PRP, and advanced biologic therapies.

Spinal Conditions
  • Neck Pain
  • Mid Back Pain
  • Low Back Pain
  • Pelvic Pain
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  • Hypermobility
  • Myofascial Pain
    • Trigger Point
      injections
    • What is Sarapin?
  • Fibromyalgia
  • EOS/Hypermobility
    Syndrome
  • Autoimmunity
    • LDN (Low dose
      Natrexone)
    • Testing
  • Prolotherapy
  • Neuroprolotherapy
  • Neural Therapy
  • Cold Laser
  • Entrapment Neuropathy
    • Carpal Tunnel Syndrome
    • Radial & Ulnar Nerve Entrapment
    • Lower Extremity Entrapment
    • Occipital Neuritis
  • Scar Tissue
  • Peripheral Neuropathy
    • Fatty Acid Testing & Specialized Therapies
    • Cold Laser
    • Nutritional Support
  • Neck Pain
  • Mid Back Pain
  • Low Back Pain
  • Pelvic Pain
  • SacroiIiac Joint Pain
  • Hypermobility
  • Inner Arsenal
  • Vagus Nerve Support
  • Power over Pain Mindset
  • Breathing Practices
Resources

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OVERVIEW

The Barr Center for Innovative Pain and Regenerative Therapies, led by Dr. Lisa Barr, is dedicated to helping people in pain. With over forty years of experience, Dr. Barr and her staff offer a range of evaluation and treatment options, including osteopathic assessment, trigger point injections, prolotherapy, and regenerative therapies. They prioritize a caring atmosphere and involve patients in their own care, ensuring they understand the recommended treatments. If necessary, they collaborate with other professionals to provide a comprehensive approach. Dr. Barr’s expertise has been recognized with the Top Doc award for thirty years.

FAQ

Pain Management and Treatment

The Barr Center for Innovative Pain & Regenerative Therapies is located at:

933 First Colonial Road, Suite 200
Virginia Beach, VA 23454

Phone: 757-578-2260
Email: info@BarrCenter.com

Monday–Thursday: 8:30 am–5:00 pm

Friday: Closed (note: physician on call)

Not always. Some insurance plans—especially HMOs—require a referral before seeing a specialist. To confirm what your specific plan requires, call your insurance provider or contact our office at 757-578-2260.

We accept most major insurance plans (except Medicaid). If your plan requires a referral or pre-authorization to see a specialist, you will need one for your first visit. After your initial consultation, our office obtains any future pre-authorizations, sometimes with assistance from your referring provider. Visit our Patient Resources page for details.

Yes. We offer telemedicine visits for certain appointment types, including follow-up visits and treatment discussions. Some procedures require in-office evaluation, and our team will help determine whether a virtual visit is appropriate.

Conditions and Treatment Questions

Led by pain management specialist Lisa Barr, M.D., the Barr Center provides comprehensive musculoskeletal and pain treatments including:

• Acupuncture
• Mind-body medicine and lifestyle optimization
• Interventional spinal procedures
• Sports medicine
• Physical therapy
• Regenerative medicine (PRP, prolotherapy)

We treat a wide range of pain and musculoskeletal conditions, including:

• Neck, shoulder, hip, back, and knee pain
• Sports injuries and repetitive strain conditions
• Posture, sleep, and movement-related pain
• Car accident injuries, including whiplash

Our approach provides proven alternatives to surgery and long-term medications through targeted injections, hands-on physical therapy, acupuncture, lifestyle guidance, and regenerative medicine.

If your pain is persistent, recurring, or limiting daily activities, it is time for an evaluation. We assess how your joints move, how your muscles function, and whether lifestyle factors are contributing to your symptoms.

We offer a comprehensive, root-cause approach to pain in a boutique practice setting.

Our team is highly specialized, and we combine interventional pain medicine, regenerative therapies, physical therapy, and whole-person care—all under one roof.

Our team includes board-certified physicians, licensed physical therapists, regenerative medicine specialists, acupuncture providers, and experienced clinical support staff with focused expertise in musculoskeletal medicine and pain management.

Preparing for your First Appointment

To help make your first visit efficient, please bring:

• Photo ID
• Insurance card
• Referral (if required by your insurance)
• Completed new-patient paperwork
• Co-pay, if applicable

If you have MRIs, CT scans, X-rays, or lab results, please have your referring provider fax them to our office. You may also download our Medical Records Request Form to expedite the process.

Experiencing Pain? Reach Out For Medication-Free Treatment